Breast density is a strong risk factor for breast cancer and is also a marker for breast cancer development. The purpose of this study is to determine how metabolites in the blood are associated with breast density. Metabolites are small chemicals in the blood which play critical roles in keeping our cells healthy and functioning properly.

Study Goal

Study findings will help us understand why some women have dense breasts while others do not. It will, thus, lay the groundwork to determine whether metabolites that can be intervened upon are associated with breast density and ultimately breast cancer risk, thus contributing to breast cancer prevention in younger women.


You may be eligible to participate if you:

  • Are a premenopausal woman
  • Are scheduled to have a mammogram at the Breast Health Center (BHC) at Siteman Cancer Center

What will I be asked to do?

If you agree to participate you will:

  • Complete your routine mammogram (allowing the study team access to your mammogram images)
  • Complete a survey that should take no longer than 30 minutes
  • Have your blood drawn at a study visit
  • Provide a urine sample (optional)

Coordinator Contact Information:

Alena Ahrens
Phone: 314-286-2779

Metabolomics Study Recruitment (May 2022)

RACENumber (%)
Non-Hispanic White302 (74%)
Non-Hispanic Black86 (21%)
Hispanic6 (1%)
Asian9 (2%)
American Indian/Alaska Native/Pacific Islander1 (0%)
Other5 (1%)

Funding: NIH/NCI R01CA246592 (PI: Toriola)